Transforming growth factor beta 1 expression in gastric carcinoma

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Transforming growth factor beta 1 expression in gastric carcinoma.

Many types of human malignant tumor have been reported to amplify transforming growth factor-beta 1 (TGF-beta 1) gene and overexpress its protein. However, little work has been done about the content of TGF-beta 1 protein in tissue and blood of patients with malignant tumors. TGF-beta 1 protein of tissue (n = 29) and serum TGF-beta 1 levels in patients with gastric carcinoma (n = 62) were compa...

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Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma.

Transforming growth factor-beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose effects include angiogenesis. The expression of TGF-beta 1 in gastric carcinomas (70 cases) has been determined and related to pathological features and microvessel count by immunohistochemical staining for TGF-beta 1 and Factor VIII related antigen. Prominent reactivity for TGF-beta 1 was...

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Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

Transforming growth factor beta 1 (TGF-beta 1) is a potent growth inhibitor for many cell types, including tumor cells. We recently have reported the establishment and characterization of two human gastric scirrhous carcinoma cell lines, HSC-39 and HSC-43. Here we examined the effect of TGF-beta 1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell lines. Pr...

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Expression of Transforming Growth Factor Beta 1 in Vitiligo

Background: Vitiligo is characterized by selective destruction of melanocytes. Transforming growth factor beta 1 (TGFβ 1) is the main product of regulatory T cells (Tregs) which are deficient in vitiligo. Thus, lower levels of serum TGFβ 1 are expected in vitiligo. However, TGFβ 1 is a keratinocytederived cytokine with inhibitory effect on melanocyte activity. Thus it may be expected to be high...

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ژورنال

عنوان ژورنال: Journal of Korean Medical Science

سال: 1997

ISSN: 1011-8934,1598-6357

DOI: 10.3346/jkms.1997.12.3.215